abstract：:Coronary involvement may appear in up to a third of patients with Takayasu's arteritis. This affliction may have a dominant impact on the clinical manifestations of the patient. Occlusion of the ostia of the left main coronary artery and of proximal segments of the coronary arteries is the most frequent finding of the...

journal_title：Autoimmunity reviews

authors： Rav-Acha M,Plot L,Peled N,Amital H

更新日期：2007-09-01 00:00:00

abstract：:Heat-shock protein (Hsp) family is made up of heterogeneous proteins of which Hsp60 members are the most studied. It is now generally admitted that Hsp60 is not only a mitochondrial component but can be localized on the membrane cell surface. Considered as a signal danger following infections, Hsp60 can induce the pro...

journal_title：Autoimmunity reviews

authors： Alard JE,Dueymes M,Youinou P,Jamin C

更新日期：2007-08-01 00:00:00

abstract：:Hyperhomocysteinemia is independently associated with the development of coronary, cerebral and peripheral vascular disease and deep-vein thrombosis in the general population. The evidence that cardiovascular involvement is particularly frequent and advanced in patients affected with several autoimmune diseases (AD), ...

journal_title：Autoimmunity reviews

authors： Lazzerini PE,Capecchi PL,Selvi E,Lorenzini S,Bisogno S,Galeazzi M,Laghi Pasini F

更新日期：2007-08-01 00:00:00

abstract：:Arrays are one of the technologies able to detect autoantibodies by measuring simultaneously many thousands of markers from a unique biological sample. The main purpose of a diagnostic test is making an early and accurate diagnosis. From a statistical point of view, multiple testing increases the probability of false ...

journal_title：Autoimmunity reviews

authors： Bidoli E,Villalta D,Ethical Committee of Pordenone Hospital, Italy.,Battistin M,Bidoli E,Cammarota A,Ciccone M,Fedato R,Lodi B,Marchesini F,Molaro G,Ostardo E,Rellini G,Sartori R,Schinella D

更新日期：2007-06-01 00:00:00

abstract：:Experimental analyses and literature survey reveal low-redundancy to the host proteins as a common denominator of immunogenic sequences mapped along tumor-, autoimmune-, and infectious disease-associated-proteins. The hypothesis that immunogenicity of peptide sequences is linked to proteomic redundancy is discussed. ...

journal_title：Autoimmunity reviews

authors： Kanduc D,Lucchese A,Mittelman A

更新日期：2007-04-01 00:00:00

abstract：:Neuropsychiatric syndromes are prevalent in pediatric patients with systemic lupus erythematosus (SLE) and often manifest early in disease course and with significant associated morbidity. Postulated pathogenic mechanisms of peripheral and central nervous system events include vasculopathy, autoantibody effects and sy...

journal_title：Autoimmunity reviews

authors： Muscal E,Myones BL

更新日期：2007-03-01 00:00:00

abstract：:Major breakthroughs have occurred with classification of B-cells into populations and subpopulations. With respect to their expression of CD5, they comprise the B1 and B2 populations, with the former further divided into B1a and B1b subpopulations. The oncologic process starts from transitional type 1 (T1) and T2 imma...

journal_title：Autoimmunity reviews

authors： Le Pottier L,Devauchelle V,Pers JO,Jamin C,Youinou P

更新日期：2007-01-01 00:00:00

abstract：:Catastrophic antiphospholipid syndrome (CAPS) (Asherson's Syndrome), is a life-threatening condition characterized by a rapidly progressive thromboses resulting in a multiorgan dysfunction syndrome (MODS), evidence of systemic inflammatory response syndrome (SIRS) in the presence of antiphospholipid antibodies. CAPS d...

journal_title：Autoimmunity reviews

authors： Makatsariya A,Asherson RA,Bitsadze V,Baimuradova S,Akinshina S

更新日期：2006-12-01 00:00:00

abstract：:Antiphospholipid syndrome is characterized with thrombotic events and/or pregnancy morbidity and antiphospholipid antibodies (aPL). The most common antigen for aPL is beta2-glycoprotein-I (beta(2)GPI), a plasma protein binding to negatively charged phospholipids. The influence of aPL on coagulation is not well underst...

journal_title：Autoimmunity reviews

authors： Ambrozic A,Cucnik S,Tomsic N,Urbanija J,Lokar M,Babnik B,Rozman B,Iglic A,Kralj-Iglic V

更新日期：2006-11-01 00:00:00

abstract：:In Multiple Sclerosis (MS) patients, conventional magnetic resonance imaging (MRI) shows a pattern of white matter (WM) disruption but may also overlook some WM damage. Diffusion tensor MRI (DT-MRI) can provide important in-vivo information about fiber direction that is not provided by conventional MRI. The geometry o...

journal_title：Autoimmunity reviews

authors： Goldberg-Zimring D,Warfield SK

更新日期：2006-10-01 00:00:00

abstract：:Based on new biologic and clinical insights, the number of drugs blocking different biologic targets in rheumatoid arthritis (RA) [e.g., tumor necrosis factor alpha (TNFalpha), CTLA4, interleukin (IL)-1, IL-6, IL-15, IL-18, B lymphocyte stimulator (BLyS), CD20] has increased considerably over the last decade. Rituxima...

journal_title：Autoimmunity reviews

authors： De Vita S,Quartuccio L

更新日期：2006-08-01 00:00:00

abstract：:Ets transcription factors function throughout development in such varied processes as cellular proliferation, apoptosis, differentiation and migration. Many have been implicated to play important roles in hematopoiesis, vasculogenesis/angiogenesis and myogenesis. Fli1 is an Ets family member that is essential for deve...

journal_title：Autoimmunity reviews

authors： Nowling TK,Gilkeson GS

更新日期：2006-07-01 00:00:00

abstract：:Pulmonary manifestations in antiphospholipid syndrome (APS) are relatively rare compared to other clinical signs of this disease. However, pulmonary microthrombosis is among the most frequent arterial complications of APS. Timely diagnosis of pulmonary manifestations is required due both to their severity and to the h...

journal_title：Autoimmunity reviews

authors： Stojanovich L

更新日期：2006-05-01 00:00:00

abstract：:One of the most enigmatic problems in rheumatology has been juvenile idiopathic arthritis (JIA). Firstly, the classification has often depended on clinical features that have variations between patients. Secondly, there are different classification schemes in usage and there are few objective serologic tests that help...

journal_title：Autoimmunity reviews

authors： Borchers AT,Selmi C,Cheema G,Keen CL,Shoenfeld Y,Gershwin ME

更新日期：2006-04-01 00:00:00

abstract：:Coeliac disease is a gluten-sensitive enteropathy characterized by villous atrophy, hyperplastic crypts and increased numbers of intraepithelial lymphocytes which are reversed by gluten withdrawal. Diverse autoimmune disorders are frequently associated with the disease, and patients also carry an increased risk of gas...

journal_title：Autoimmunity reviews

authors： Periolo N,Cherñavsky AC

更新日期：2006-03-01 00:00:00

abstract：:T cells from patients with SLE produce decreased amounts of interleukin-2 (IL-2), a central cytokine in the regulation of the immune response. We discuss herein the abnormalities underlying IL-2 deficiency in SLE T cells. ...

journal_title：Autoimmunity reviews

authors： Katsiari CG,Tsokos GC

更新日期：2006-02-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIg) is used for replacement therapy in immunodeficiency states and for immunomodulation of various autoimmune diseases. Several case reports and series support a beneficial role of IVIg in systemic lupus erythematosus (SLE), both as salvage immunotherapy and in control of disease activity...

journal_title：Autoimmunity reviews

authors： Sherer Y,Shoenfeld Y

更新日期：2006-02-01 00:00:00

abstract：:There is strong evidence that a quantitative and/or functional deficiency in CD4+CD25+ regulatory T cells (T(reg) cells) plays a key role in the pathogenesis of many human autoimmune diseases. Therefore, targeting regulatory T cells with novel forms of immunotherapy should provide a means for successfully battling aut...

journal_title：Autoimmunity reviews

authors： Beyersdorf N,Hanke T,Kerkau T,Hünig T

更新日期：2006-01-01 00:00:00

abstract：:This article reviews the role of CD20 antigen in B cell function and the effectiveness and limits of passive immunotherapy with anti-CD20 monoclonal antibody (Rituximab) in the treatment of autoimmune (or immune-mediated) diseases. Active immunotherapy is a more feasible way to control these chronic diseases. A peptid...

journal_title：Autoimmunity reviews

authors： Perosa F,Favoino E,Caragnano MA,Prete M,Dammacco F

更新日期：2005-11-01 00:00:00

abstract：:Hematopoietic stem cell transplant (HSCT) for autoimmune diseases has been recognized as a potential treatment for patients who have failed conventional therapy. Autologous (self) donor cells have been preferred over allogeneic (HLA-matched) cells for rescue after high dose immunotherapy, given the previous higher rat...

journal_title：Autoimmunity reviews

authors： de Buys P,Khanna D,Furst DE

更新日期：2005-09-01 00:00:00

abstract：:In the past decade significant advantages have been made in the treatment of rheumatoid arthritis (RA) and therapeutic strategies have changed a lot. These days, highly effective disease modifying anti-rheumatic drugs enable intervention early in the disease process, in order to prevent major joint damage. For years, ...

journal_title：Autoimmunity reviews

authors： Vallbracht I,Helmke K

更新日期：2005-07-01 00:00:00

abstract：:T cells play a central role in the immunopathogenesis of AIH. Until recently CD4+ T cells were thought to be critical for disease development, increasing evidence has shown that CD8+ T and gammadelta T cells also play a significant role. The predisposition of certain HLA genotypes to AIH as well as the clonal expansio...

journal_title：Autoimmunity reviews

authors： Ichiki Y,Aoki CA,Bowlus CL,Shimoda S,Ishibashi H,Gershwin ME

更新日期：2005-06-01 00:00:00

abstract：:Impaired clearance of apoptotic cell material has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Besides many other molecules, C1q and DNaseI contribute to an efficient clearance of dying cells. A frequently observed factor in SLE patients is the accumulation of unusually large amounts of a...

journal_title：Autoimmunity reviews

authors： Gaipl US,Voll RE,Sheriff A,Franz S,Kalden JR,Herrmann M

更新日期：2005-04-01 00:00:00

abstract：:Viral infections are involved in the pathogenesis of blood autoimmune diseases such as hemolytic anemia and thrombocytopenia. Although antigenic mimicry has been proposed as a major mechanism by which viruses could trigger the development of such diseases, it is not easy to understand how widely different viruses migh...

journal_title：Autoimmunity reviews

authors： Musaji A,Meite M,Detalle L,Franquin S,Cormont F,Préat V,Izui S,Coutelier JP

更新日期：2005-04-01 00:00:00

abstract：:TNF-alpha is a crucial cytokine in the establishment and maintenance of inflammation in multiple autoimmune and non-autoimmune disorders. A number of large placebo-controlled trials have shown that infliximab, a chimeric monoclonal antibody against TNF-alpha, is effective and well-tolerated in patients with Crohn's di...

journal_title：Autoimmunity reviews

authors： Atzeni F,Sarzi-Puttini P,Doria A,Iaccarino L,Capsoni F

更新日期：2005-03-01 00:00:00

abstract：:Annexin V inhibits prothrombin activation and is able to prevent thrombus formation under normal venous and arterial blood flow conditions. Antibodies to annexin V have been identified in association with several pathological conditions, including systemic lupus erythematosus (SLE) with or without anti-phospholipid sy...

journal_title：Autoimmunity reviews

authors： Esposito G,Tamby MC,Chanseaud Y,Servettaz A,Guillevin L,Mouthon L

更新日期：2005-01-01 00:00:00

abstract：:The classical view of B cells in the biology of autoimmune responses to infectious and self-antigens (Ag) that they promote immunity primarily by producing antibodies (Ab) is far from being complete. Indeed, studies over the last decade suggest that B cells have extraordinarily diverse functions within the immune syst...

journal_title：Autoimmunity reviews

authors： Renaudineau Y,Pers JO,Bendaoud B,Jamin C,Youinou P

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To address changes in survival of patients with systemic lupus erythematosus (SLE) and to compare mortality statistics with associated disease specific as well as comorbid conditions. METHODS:Review of the international literature on survival of patients with SLE. RESULTS:During the first half of the 20th c...

journal_title：Autoimmunity reviews

authors： Borchers AT,Keen CL,Shoenfeld Y,Gershwin ME

更新日期：2004-08-01 00:00:00

abstract：:The aim of this work was to review the inflammatory factors involved in central nervous system (CNS) inflammation and the damage associated to their participation in an inflammatory disease of CNS, multiple sclerosis in humans and experimental allergic encephalomyelitis in the murine model. Inflammation has an importa...

journal_title：Autoimmunity reviews

authors： Chavarria A,Alcocer-Varela J

更新日期：2004-06-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) has been coined a model autoimmune disease. In fact, it does share many similarities with other autoimmune diseases, but there are striking differences that illustrate the uniqueness of the immunopathology. Firstly, similar to other autoimmune diseases, there is an intense humoral and c...

journal_title：Autoimmunity reviews

authors： Ichiki Y,Shimoda S,Ishibashi H,Gershwin ME

更新日期：2004-06-01 00:00:00

abstract：:Multidrug resistance-1 (MDR-1) is characterized by overfunction of P-glycoprotein (P-gp), a pump molecule that decreases intracellular drug concentration by effluxing them from the intracellular space. Broad ranges of structurally unrelated compounds are transported by P-gp, including antineoplastic agents, HIV protea...

journal_title：Autoimmunity reviews

authors： Richaud-Patin Y,Soto-Vega E,Jakez-Ocampo J,Llorente L

更新日期：2004-03-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is a clinicopathologic entity characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. Uncontrolled T-lymphocyte activation is responsible for increased T(H)1 cytokines secretion such as IFN-gamma, IL-12...

journal_title：Autoimmunity reviews

authors： Larroche C,Mouthon L

更新日期：2004-02-01 00:00:00

abstract：:Autoimmunity results from a deficiency in tolerance establishment, i.e. a failure of the organism to eliminate or functionally neutralize auto-reactive lymphocytes. Dendritic cells (DC) are specialized migratory antigen presenting cells (APC), found as sentinels in peripheral tissues and lymphoid organs that allow the...

journal_title：Autoimmunity reviews

authors： Jung S

更新日期：2004-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) and the autoimmune thyroid diseases (AITD) are the most common autoimmune endocrine diseases. Both are organ-specific T-cell mediated diseases. Abundant epidemiological data support a strong genetic basis for both T1D and AITD. Furthermore, both diseases commonly occur in the same individuals and...

journal_title：Autoimmunity reviews

authors： Levin L,Tomer Y

更新日期：2003-10-01 00:00:00

abstract：:Numerous inflammatory rheumatic diseases occurring in premenopausal women require the use of high doses of glucocorticoids (GC). It was believed for many years that premenopausal women were, at least to some extent, protected from bone loss associated with GC therapy. However, epidemiological studies performed in prem...

journal_title：Autoimmunity reviews

authors： Franchimont N,Canalis E

更新日期：2003-06-01 00:00:00

abstract：:Circulating antibodies specific to retinal proteins have been associated with retinal dysfunction in patients with retinopathy. Anti-recoverin antibodies found in patients with cancer-associated retinopathy (CAR) represent a unique model to study the relationship between retinal degeneration and autoimmunity. A body o...

journal_title：Autoimmunity reviews

authors： Adamus G

更新日期：2003-03-01 00:00:00

abstract：:The pathogenesis of Sjögren's syndrome is poorly understood. Genetic and environmental factors appear to contribute to the development of this syndrome. Viral infection is one of the most likely environmental factors. The primary lesion of Sjögren's syndrome is in the exocrine glands. A majority of the infiltrating ce...

journal_title：Autoimmunity reviews

authors： Yamamoto K

更新日期：2003-01-01 00:00:00

abstract：:Beta2-glycoprotein I (beta2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by beta2-GPI and anti-beta2-GPI autoantibodies. Ligands specific for beta2-GPI derived from oxLDL have be...

journal_title：Autoimmunity reviews

authors： Matsuura E,Kobayashi K,Koike T,Shoenfeld Y

更新日期：2002-12-01 00:00:00

abstract：:To enable clinicians to use autoantibody tests sensibly and economically, laboratories providing the test service have a responsibility to supply the test 'specifications'. This should include information about the test's validity and reliability, its normal range or range within a control population, its sensitivity ...

journal_title：Autoimmunity reviews

authors： Sturgess A,Edmonds J

更新日期：2002-10-01 00:00:00

abstract：:Inflammatory muscle diseases (IMD), including dermatomyositis (DM) and polymyositis (PM), affect skeletal muscle, leading to profound tissue modification. The etiology of IMD is unknown, but multiple steps of the disease pathogenesis have been identified. The main alterations involve the immune response. Cellular infi...

journal_title：Autoimmunity reviews

authors： Pignone A,Fiori G,Del Rosso A,Generini S,Matucci-Cerinic M

更新日期：2002-08-01 00:00:00